Categorie > Huntingtons Disease

Protecting The Brain From A Deadly Genetic Disease

Categorie : Huntingtons Disease
Huntington's disease (HD) is a cruel, hereditary condition that leads to severe physical and mental deterioration, psychiatric problems and eventually, death. Currently, there are no treatments to slow down or stop it. HD sufferers are born with the disease although they do not show symptoms until l ...

read more Huntington's disease (HD) is a cruel, hereditary condition that leads to severe physical and mental deterioration, psychiatric problems and eventually, death. Currently, there are no treatments to slow down or stop it. HD sufferers are born with the disease although they do not show symptoms until l read more Fri Mar 2010

Medication Appears Well Tolerated And May Have Beneficial Effects In Patients With Huntington's Disease

Categorie : Huntingtons Disease
A medication previously studied in patients with Alzheimer's disease (latrepirdine) appears well tolerated and may improve thinking, learning and memory skills among individuals with Huntington's disease, according to a report in the February issue of Archives of Neurology, one of the JAMA/Archives ...

read more A medication previously studied in patients with Alzheimer's disease (latrepirdine) appears well tolerated and may improve thinking, learning and memory skills among individuals with Huntington's disease, according to a report in the February issue of Archives of Neurology, one of the JAMA/Archives read more Wed Feb 2010

Huntington's Disease: Discovery Of Mechanism In Brain Cell Injury Offers New Treatment Approaches

Categorie : Huntingtons Disease
Scientists at the Brain Research Centre and Centre for Molecular Medicine and Therapeutics have uncovered a key cellular mechanism that alters brain cell function in Huntington's disease, and identified a possible treatment for the disease. The results of the study were published online today and wi ...

read more Scientists at the Brain Research Centre and Centre for Molecular Medicine and Therapeutics have uncovered a key cellular mechanism that alters brain cell function in Huntington's disease, and identified a possible treatment for the disease. The results of the study were published online today and wi read more Thu Jan 2010

Alnylam And Collaborators Present Data From Multiple Pre-Clinical And Clinical Programs At RNAi Keystone Symposium

Categorie : Huntingtons Disease
Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, today announced that it presented data from multiple pre-clinical and clinical programs at the "RNA Silencing: Mechanism, Biology, and Application" Keystone Symposium held January 14-19, 2010 in Keystone, Colorado... ...

read more Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, today announced that it presented data from multiple pre-clinical and clinical programs at the read more Sun Jan 2010

Evotec And CHDI Foundation, Inc. Extend Collaboration To Fight Huntington's Disease

Categorie : Huntingtons Disease
Evotec AG (Frankfurt Stock Exchange: EVT, TecDAX) announced the extension of its collaboration with CHDI Foundation, Inc. (CHDI) through to the end of 2012. The collaboration, which is aimed at finding new treatments for Huntington's disease and represents one of the largest joint innovation drug d ...

read more Evotec AG (Frankfurt Stock Exchange: EVT, TecDAX) announced the extension of its collaboration with CHDI Foundation, Inc. (CHDI) through to the end of 2012. The collaboration, which is aimed at finding new treatments for Huntington's disease and represents one of the largest joint innovation drug d read more Sun Jan 2010

Huntington's Disease: IKK May Act As Both Inhibitor And Promoter

Categorie : Huntingtons Disease
The kinase IKK phosphorylates the protein mutated in Huntington's disease to promote its removal and neuron survival, but IKK may be a double-edged sword that increases neurotoxicity in later stages of the disease. The study, led by researchers from the University of California, Irvine, was publishe ...

read more The kinase IKK phosphorylates the protein mutated in Huntington's disease to promote its removal and neuron survival, but IKK may be a double-edged sword that increases neurotoxicity in later stages of the disease. The study, led by researchers from the University of California, Irvine, was publishe read more Thu Dec 2009

Subtle Change Dramatically Reduces Pathogenic Potential Of Huntington's Protein

Categorie : Huntingtons Disease
Scientists have identified a key molecular switch that may drive the onset of Huntington's disease (HD), an incurable neurodegenerative disorder that leads to severe disruptions in muscle coordination and cognitive function... ...

read more Scientists have identified a key molecular switch that may drive the onset of Huntington's disease (HD), an incurable neurodegenerative disorder that leads to severe disruptions in muscle coordination and cognitive function... read more Thu Dec 2009

Cedars-Sinai Regenerative Medicine Institute To Supply Stem Cells To Scientists Developing Treatments For Huntington's Disease

Categorie : Huntingtons Disease
The Cedars-Sinai Regenerative Medicine Institute is to provide stem cells to a five-member National Institutes of Health consortium of researchers for development of potential therapies to treat Huntington's disease. As part of the $3.7 million grant from the National Institutes of Health, the C ...

read more The Cedars-Sinai Regenerative Medicine Institute is to provide stem cells to a five-member National Institutes of Health consortium of researchers for development of potential therapies to treat Huntington's disease. As part of the $3.7 million grant from the National Institutes of Health, the C read more Wed Dec 2009

Amarin Neuroscience Ltd Withdraws Its Marketing Authorisation Application For Ethyl Eicosapent Soft Capsules (ethyl Eicosapent), Europe

Categorie : Huntingtons Disease
The European Medicines Agency has been formally notified by Amarin Neuroscience Ltd of its decision to withdraw its application for a centralised marketing authorisation for the medicine Ethyl Eicosapent (ethyl eicosapent), 500 mg soft gelatine capsules... ...

read more The European Medicines Agency has been formally notified by Amarin Neuroscience Ltd of its decision to withdraw its application for a centralised marketing authorisation for the medicine Ethyl Eicosapent (ethyl eicosapent), 500 mg soft gelatine capsules... read more Wed Dec 2009

Better Understanding Of Synaptic Activity May Support 'Use It Or Lose It' Hypothesis In Huntington's Disease

Categorie : Huntingtons Disease
Investigators at Burnham Institute for Medical Research (Burnham), the University of British Columbia's Centre for Molecular Medicine and Therapeutics and the University of California, San Diego have found that normal synaptic activity in nerve cells (the electrical activity in the brain that allows ...

read more Investigators at Burnham Institute for Medical Research (Burnham), the University of British Columbia's Centre for Molecular Medicine and Therapeutics and the University of California, San Diego have found that normal synaptic activity in nerve cells (the electrical activity in the brain that allows read more Thu Nov 2009

Researchers Find Potential Treatment For Huntington's Disease

Efficacy Of Gene Therapy In Mouse Models Of Huntington's Disease Shown By Caltech Researchers

Categorie : Huntingtons Disease
Researchers at the California Institute of Technology (Caltech) have shown that a highly specific intrabody (an antibody fragment that works against a target inside a cell) is capable of stalling the development of Huntington's disease in a variety of mouse models. "Gene therapy in these models s ...

read more Researchers at the California Institute of Technology (Caltech) have shown that a highly specific intrabody (an antibody fragment that works against a target inside a cell) is capable of stalling the development of Huntington's disease in a variety of mouse models. read more Sun Nov 2009

Gladstone And Partners Receive $3.7 Million For Huntington's Disease Research

Categorie : Huntingtons Disease
The National Institutes of Health (NIH) has awarded a "Grand Opportunity" grant of $3.7 million to a consortium formed with the Gladstone Institute of Neurological Disease (GIND) and the Taube-Koret Center for Huntington's Disease Research to use stem cell technology to better understand Huntington' ...

read more The National Institutes of Health (NIH) has awarded a read more Sun Oct 2009

Disturbed Calcium Signaling May Play A Critical Role In Brain Cell Degeneration

Categorie : Huntingtons Disease
University of Utah School of Medicine researchers and their colleagues at University of Texas (UT) Southwestern Medical Center have found strong evidence that abnormal calcium signaling in neurons may play an important role in the development of spinocerebellar ataxia type 2 (SCA2), a disorder caus ...

read more University of Utah School of Medicine researchers and their colleagues at University of Texas (UT) Southwestern Medical Center have found strong evidence that abnormal calcium signaling in neurons may play an important role in the development of spinocerebellar ataxia type 2 (SCA2), a disorder caus read more Sun Aug 2009

In Huntington's Patients, Transplanted Neurons Develop Disease-Like Pathology

Categorie : Huntingtons Disease
The results of a recent study published in PNAS question the long-term effects of transplanted cells in the brains of patients suffering from Huntington's disease. This study, conducted jointly by Dr. Francesca Cicchetti of UniversitÃƒÂ© Laval in Quebec, Canada, Dr. Thomas B. ...

read more The results of a recent study published in PNAS question the long-term effects of transplanted cells in the brains of patients suffering from Huntington's disease. This study, conducted jointly by Dr. Francesca Cicchetti of UniversitÃƒÂ© Laval in Quebec, Canada, Dr. Thomas B. read more Sun Aug 2009

Pfizer And Medivation Initiate Phase 3 Trial Of Dimebon In Patients With Huntington Disease

Categorie : Huntingtons Disease
Pfizer Inc (NYSE: PFE) and Medivation, Inc. (NASDAQ: MDVN) announced the initiation of a Phase 3 trial of the investigational drug dimebon (latrepirdine) in patients with Huntington disease. The international safety and efficacy trial, known as HORIZON, is designed to evaluate the potential benefits ...

read more Pfizer Inc (NYSE: PFE) and Medivation, Inc. (NASDAQ: MDVN) announced the initiation of a Phase 3 trial of the investigational drug dimebon (latrepirdine) in patients with Huntington disease. The international safety and efficacy trial, known as HORIZON, is designed to evaluate the potential benefits read more Sun Aug 2009

Huntington's: Researchers Gain Insight Into Mechanism Underlying The Disease

Categorie : Huntingtons Disease
Researchers at the University of Kentucky Markey Cancer Center and Graduate Center for Toxicology (GCT) have gained new insight into the genetic mechanisms underlying Huntington's disease and other neurodegenerative or neuromuscular disorders caused by trinucleotide repeats (or TNRs) in DNA. The ...

read more Researchers at the University of Kentucky Markey Cancer Center and Graduate Center for Toxicology (GCT) have gained new insight into the genetic mechanisms underlying Huntington's disease and other neurodegenerative or neuromuscular disorders caused by trinucleotide repeats (or TNRs) in DNA. The read more Sat Jul 2009

Huntington's Disease Deciphered

Categorie : Huntingtons Disease
Researchers at the University of Illinois at Chicago College of Medicine have discovered how the mutated huntingtin gene acts on the nervous system to create the devastation of Huntington's disease. The report of their findings is available in Nature Neuroscience online. ...

read more Researchers at the University of Illinois at Chicago College of Medicine have discovered how the mutated huntingtin gene acts on the nervous system to create the devastation of Huntington's disease. The report of their findings is available in Nature Neuroscience online. read more Sat Jul 2009

Risk Of Discrimination For Individuals With Family History Of Genetic Disease

Categorie : Huntingtons Disease
A research published on bmj.com reports that individuals with a family history of genetic disease are frequently discriminated by their relatives, friends and also by insurance companies. Many individuals have been able to adapt treatment and inform reproductive decisions thanks to the developme ...

read more A research published on bmj.com reports that individuals with a family history of genetic disease are frequently discriminated by their relatives, friends and also by insurance companies. Many individuals have been able to adapt treatment and inform reproductive decisions thanks to the developme read more Sat Jul 2009

Transmission Of Huntington's Disease To Offspring Among Male Carriers: Risk Estimated By Researchers

Categorie : Huntingtons Disease
Researchers from Boston University School of Medicine (BUSM) have quantified the probability of a male who carries a "high normal" variant of the Huntington's Disease (HD) gene having a child who develops the disease. Although thought to be a very rare event, the probability has never been estimated ...

read more Researchers from Boston University School of Medicine (BUSM) have quantified the probability of a male who carries a read more Sat Jul 2009

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